Liposphere –
Biolubrication starts

Liposphere is a biomedical start-up spun out from the Weizmann Institute of Science (Israel) in early 2019. Its unique IP-protected platform technology of unmatched biolubricants has been developed over the past two decades at the Department of Materials & Interfaces under Professor Jacob Klein. Based on the profound knowledge of Klein and his team, Liposphere is now developing an innovative platform of highly lubricious, water-based lipid-based biomaterials for conditions in or in interaction with the human body where smooth motion between surfaces is required.

Learn more on
Liposphere’s technology:

„Answering unmet medical needs“

There is an urgent, global, unmet medical need to develop innovative solutions, which can sustain forces within mechanically stressed environments. In the context of the human body, the major synovial joints such as the knee or hip joint articulate under high-load and shear stress conditions. whereas the cornea/eye lid interface for example is exposed to high shear stresses under high-load and stress conditions. When physiologically impaired conditions in the orthopaedic field are the exact pain points where Liposphere’s formulations can play a crucial role.


Liposphere’s formulation can be used as a pure boundary, but also has the potential to encapsulate active pharmaceutical ingredients in the future, for delivery of pharmaceuticals to targets that currently are difficult to reach. In addition, Liposphere’s platform technology, named Coat by Liposphere, enables the coating of synthetic, medical surfaces such as orthopaedic implants, giving the potential for smooth movement in a wide range of biomedical devices.


„You are looking for an investment
high potential growth? Join us
be part of our innovative vision.“

Introducing our unique product
The platform technology  Coat by Liposphere


Liposphere’s platform technology Coat by Liposphere can be used as a pure lubricant to coat biological surfaces, but also provides the vehicle to encapsulate active pharmaceutical ingredients or supplements to be delivered.

In addition, Liposphere’s platform technology enables the robust coating of artificial medical surfaces such as implants, catheters, hydrogels and needles, leading to ultra-low friction and improved lubrication when coated surfaces slide past each other in an Coat system.


Biological surfaces

We develop CCoat (Investigational Device) as an intra-articular injectable for the treatment of knee Osteoarthritis. CCoat acts as a biocompatible, boundary lubricant coating the cartilage surfaces of the opposing bones of the knee joint, hence reducing friction and wear by providing superior lubrication.

// Reducing wear significantly by protecting cartilage

Artificial surfaces

With the product line SCoat (Investigational Device), Liposphere develops highly lubricious coatings for artificial surfaces relevant in different healthcare applications. Liposphere has recently conducted a pilot studies with commercial partners to assess SCoat on different materials in use as artificial joint implants.

// Coating artificial surfaces with ultra-low friction materials

News from Liposphere

Winner of ATiO’s „Best Early-Stage Company Award“!
Excitement about AqueousJoint’s development among a high-profile orthopedic community.

Liposphere presented its AqueousJoint knee joint injectable at the Alliance for Advanced Therapies in Orthopedics (ATiO, https://atioalliance.org/) conference in Berlin. Following competitive rounds of presentations, the Company won the Best Early-Stage Company award judged by a high-profile orthopedic audience and received the „Dancing Bear“ trophy.

Approval of multi-centered, double-blinded clinical trial
150 patients will be recruited at different clinical sites in Israel.

The Israeli Ministry of Health approved our efficacy-focused clinical trial protocol. The trial will be a multi-center, double-blinded, and randomized study, and the primary outcome is to show the superiority of the CCoat product compared to a saline solution (Placebo). Moreover, low, and high dosages of AqueousJoint will be used to identify the optimum product concentration.
Each group will recruit 50 patients to achieve statistically meaningful results.
The first clinical site in Assuta Hospital, Ashdod, was initiated. Further sites are Kaplan Hospital, Rehovot, Tel-Hashomer, Ramat-Gan, and Asaf Harofe Beer-Yacov, which will open soon to expedite recruitment.

First-In-Human clinical trial successfully completed
Promising clinical outcome!

20 Patients with diagnosed Osteoarthritis were enrolled in our First-In-Human safety trial in which the AqueousJoint product was clinically evaluated for the first time. Those patients received a single AqueousJoint injection into their knee joint cavity.
A follow-up time of 6 months was completed successfully, confirming the product’s safety (no related adverse events reported) and a long-lasting pain reduction effect of 6 months. The efficacy output was assessed using standardized questionnaires: The Knee Injury and Osteoarthritis Outcome Score (KOOS) and a Numeric Visual Scale (NVS) measure.









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Liposphere Ltd.
Aarava 1
6th Floor
Givat-Shmuel 5400804

Office:  +972 (0) 732113227

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