Weifeng Lin, Ronit Goldberg and Jacob Klein jointly published a paper in Journal of Materials Chemistry B demonstrating dramatically prolonged retention times of pMPCylated liposomes following intra-articular injection in mice joints. Congratulations!
where Biolubrication starts
Liposphere is a biomedical start-up spun out from the Weizmann Institute of Science (Israel) in early 2019. Its unique IP-protected platform technology of unmatched biolubricants has been developed over the past two decades at the Department of Materials & Interfaces under Professor Jacob Klein. Based on the profound knowledge of Klein and his team, Liposphere is now developing an innovative platform of highly lubricious, water-based biocompatible nanomaterials -named AqueousTech– for conditions in or in interaction with the human body where ultralow friction is crucial.
„Answering unmet medical needs“
There is an urgent, global, unmet medical need to develop innovative solutions, which can sustain forces within mechanically stressed environments. In the context of the human body, the major synovial joints such as the knee a or hip joint articulate under high-load conditions, whereas the cornea/eye lid interface for example is exposed to high shear stresses under low loads. Both scenarios when physiologically impaired are the exact pain points where Liposphere’s formulations can play a crucial role.
Liposphere’s formulation can be used as a pure lubricant, but also has the potential to encapsulate active pharmaceutical ingredients in the future, for delivery of pharmaceuticals to targets that currently are difficult to reach. In addition, Liposphere’s platform technology enables the coating of artificial medical surfaces such as catheters and protheses, giving the potential for smooth movement in a wide range of biomedical devices.
Introducing our unique product
The platform technology AqueousTech
Liposphere’s platform technology AqueousTech can be used as a pure lubricant to coat biological surfaces, but also provide the vehicle to encapsulate active pharmaceutical ingredients or supplements and to deliver these to targets that currently are difficult to reach.
In addition, Liposphere’s platform technology enables the robust coating of artificial medical surfaces such as catheters, hydrogels and needles, leading to ultra-low friction and improved lubrication when coated surfaces slide past each other in an aqueous system.
We develop AqueousJoint (Investigational Device) as an intra-articular injectable for the treatment of knee Osteoarthritis. AqueousJoint acts as a biocompatible, boundary lubricant coating the cartilage surfaces of the opposing bones of the knee joint, hence reducing friction and wear by providing superior lubrication.
// Reducing friction significantly by protecting cartilage
AqueousEye (Investigational Device) is a topical biolubricant under development for patients, who suffer from mild to moderate Dry Eye Syndrome. The formulation hydrates and lubricates the cornea and aims to prolong retention time.
// Treating Dry Eye Syndrome efficiently
With the product line AqueousSurface (Investigational Device), Liposphere develops highly lubricious coatings for artificial surfaces relevant in different healthcare applications. Liposphere is currently conducting and establishing pilot studies with distinct commercial partners in the catheter and contact lens manufacturing sector.
// Coating artificial surfaces with ultra-low friction materials
News from Liposphere
Liposphere manufactured its first clinical batch of AqueousJoint. Liposphere’s new injectable will be evaluated clinically in First-In-Human trials in Ichilov Hospital Tel Aviv over the next months. How exciting!
Liposphere with its AqueousJoint development project was chosen to join the IDEA2 program and participated in workshops throughout 2021. IDEA2 is a program based at the Massachusetts Institute of Technology. It provides transformative mentorship and expertise to emerging innovation leaders to develop their project ideas.
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