Who we are
Developing unique biolubricants
for diverse applications and markets
Liposphere Ltd. is an innovative female-led, biomedical Israeli start-up spun out from the Weizmann Institute of Science in early 2019. The company has developed AqueousTech as a unique platform technology of unmatched, water-based biolubricants to deliver ultra-low friction and efficient lubrication relevant for various medical and technological applications. Liposphere focuses on the orthopaedic and ophthalmic sectors based on market considerations.
The remarkable discovery of the Hydration Lubrication Mechanism and its resulting technology, for which the company holds the exclusive IP license, has been established over the past two decades under the guidance of Prof. Jacob Klein at the Department of Materials & Interfaces, Weizmann Institute of Science.
Liposphere’s management team with co-founders Dr. Ronit Goldberg (CEO) and Dr. Sabrina Jahn as well as CTO Dr. Anastasia Kipnis has worked together in Prof. Klein’s academic setting for several years before spinning out Liposphere. Liposphere is funded by the Israeli Innovation Authority and private investors.
The Spinoff Prize 2020, organized by Nature in partnership with Merck KGaA has highlighted Liposphere as one of the 44 most exciting, science-based firms spun out from academic environments.
A ”One to Watch 2020”!
„Our knowledge of hydration behavior
paves the way for us to develop products that
can hold water much more efficiently
than current solutions on the market!“
What we do
Liposphere’s Management Team
Ronit Goldberg, PhD
PhD in Chemistry, Weizmann Institute
// Ronit is an expert in liposome research and development, in particular focusing on liposomes as efficient water-based boundary lubricants. She has over 10 years of experience in leading and managing applied POC projects.
Sabrina Jahn, PhD
PhD in Physics, University of Cambridge
// Sabrina has profound experience in identifying new interdisciplinary research and product opportunities. She has a strong track record in successful governmental and private fundraising.
Anastasia Kipnis, PhD
PhD in Chemistry, Weizmann Institute
// Anastasia has extensive experience in medical device development, manufacturing processes and clinical trials, gained at Cartiheal Ltd.. She directed the R&D strategy as an Innovation team leader at Allerguard Ltd. and CartiHeal Ltd. before joining Liposphere.
„We are supported by a highly
experienced team of scientific,
clinical and business advisors.“
Head of Regulation and Quality Assurance
MSc in Biochemistry,
The Hebrew University of Jerusalem
// Inbal is a highly qualified medical device and pharmaceutical professional specialized in regulatory and quality compliance, aseptic processing, clean rooms control and validation. At Liposphere, Inbal manages the quality system and assures its compliance with Medical Device Regulations, including cGMP and GCP compliance, ISO, process validation, V&V and auditing.
Our mission and goals
Aiming for market leadership
Surfaces in motion are highly prevalent in nature and technology. In biological systems, concepts of friction, lubrication and wear are of utmost importance to maintain physiological function. In case of impairment of these concepts, pathological conditions can arise. Clinically, high friction of sliding surfaces is often associated with pain for the patient.
Our joint vision is to directly address this general problem, either in the ophthalmic, orthopaedic or technological sector, by using our unique, biocompatible, superlubricious AqueousTech formulations to reduce wear and lower friction while improving lubrication and the outcome overall.
At Liposphere, we aim to ultimately revolutionize the market of water-based lubricants. With regard to technological or industrial applications, our approach of using hydration water as the lubricating element is part of the effort shifting the paradigm from oil-based lubrication towards the sustainable, green solution using water-based lubricants.
Science & Technology
Deep expertise in biolubrication
The scientific core of Liposphere’s technology is based on the discovery of the groundbreaking Hydration Lubrication Mechanism, published in several papers in Science and Nature in recent years (1-3). This has led to the development of Liposphere’s products (currently Investigational Devices, not for sale). Hydration lubrication allows for the understanding of friction and lubrication processes in aqueous media and biological systems.
Sub-nanometer thick hydration layers able to resist high loads and pressures serve as the lubricating elements that form around charges and zwitterionic groups due to the large electric dipole of the water molecule.
These hydration layers are the crucial element behind of the hydration lubrication mechanism. Hydrated charges between sliding, confined surfaces can hence bear a large normal load, while maintaining its strongly attached hydration layer. Under shear these compressed hydration layers respond in a fluid manner as long as its relaxation rate exceeds the shear rate (4).
This combination of sustaining a large normal load, together with a fluid response to shear, results in striking lubrication properties. Applying this knowledge allows Liposphere to manufacture highly hydrated, superlubricious biomaterials.
Would you like to contact us? Call us or send us a message using the contact form – looking forward to hear from you.
Pinhas Sapir 3
1st Floor @ Daren Labs
Ness Ziona 7403626, Israel
Office: +972 (0) 8 – 616 0500