Coat by Liposphere
Introducing our platform technology
Coat by Liposphere physically adsorbs and coats biological as well as artificial surfaces to form a robust boundary layer with extremely effective lubrication at the interfaces as they slide past each other. This boundary layer can protect surfaces from wear and tear under mechanical stresses and can be applied as a pure lubricant, surface coating or combined drug delivery/lubrication vehicle.
Coat by Liposphere formulations are composed of lipid bilayers, which form stable and durable 3D spheres (liposomes), while exposing conjugated zwitterionic polymers at their surface in an aqueous environment. These zwitterionic polymers allow for the structural stabilisation of the liposomes, but also provide together with the properties of the lipid head groups as such the actual components for superior hydration and hence lubrication.
Liposphere’s formulations are capable of lowering high tear and wear forces by 3-5 orders of magnitude as scientifically shown (5). The formulations have been proven stable and homogeneous at room temperature over a long period of time. In-vitro, the survival of different cell types after exposure to Coat by Liposphere fulfils the requirements to be considered biocompatible and safe according to ISO guidelines relevant for market approval.
„We develop unique biomaterials,
which reduce friction and wear efficiently within and/or interacting with the body.“
Our innovation in 3 Minutes
Liposphere‘s current applications
Reducing wear to enable smooth motion
Reducing wear to
enable smooth motion
CCoat (Investigational Device) will target the Osteoarthritis market as an intra-articular injectable. CCoat acts as a boundary lubricant, which directly protects the cartilage surface of the knee. Current approved injectable competitor products based on hyaluronic acid are primarily viscous supplements, hence being subject to the fast metabolic turn-over of the synovial fluid of the joint.
After local administration in the knee joint of an animal model, we have shown prolonged retention time of up to 50x compared to the present solution on the market. The global viscosupplementation market was valued at USD 3.5 billion in 2018 and is expected to grow at a CAGR of 9.1% to reach an estimated value of USD 7.1 billion by 2026 (6).
The market is anticipated to boom due to an increase in geriatric population. Almost 90% of prescriptions of viscosupplements are intended for the treatment of knee Osteoarthritis.
// Reducing wear significantly by protecting cartilage
Contact us
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Liposphere Ltd.
Aarava 1
6th Floor
Givat-Shmuel 5400804
Israel
Office: +972 (0) 732113227
E-Mail: contact@lipo-sphere.com