CCoat® by Liposphere
Introducing our platform technology
Pre-clinical (in vitro and in vivo) studies demonstrated that CCoat® by Liposphere forms a coating layer on biological as well as artificial surfaces, providing a lubricating interface under mechanical stresses as these surfaces move relative to each other. Based on their highly hydrated nature, liposomes provides lubrication at the interface under mechanical stresses. It may be applied as a biocompatible joint therapy or combined drug delivery and lubrication system.
CCoat® is composed of lipid bilayers that form stable three-dimensional spheres (liposomes) while exposing conjugated zwitterionic polymers at their surface in an aqueous environment. These zwitterionic polymers contribute to the structural stabilization of the liposomes and, together with the lipid head groups, support the formation of a highly hydrated lubricating interface.
Liposphere’s products have demonstrated in vitro tribological performance under specified laboratory test conditions.
Biocompatibility of CCoat® has been evaluated in accordance with applicable ISO 10993 series standards, and all required biocompatibility endpoints were assessed and met acceptance criteria, supporting its safety for the intended use. In vitro studies further confirmed the viability of relevant cell types following exposure to CCoat®.
The product has also been shown to be stable and homogeneous at room temperature over an extended period.
We develop unique biomaterials that
improve joint functionality.
Our innovation in 3 Minutes
Liposphere‘s current applications
Pain reduction and improved functionality of the knee joint
Liposphere’s patented
joint articulation injectable
CCoat® is designed for use in patients with mild to moderate knee osteoarthritis to reduce pain and improve mobility. Acting through a purely physical mechanism of action demonstrated in pre-clinical testing, it forms a lubricating coating at the cartilage interface to support wear reduction under non-clinical conditions.
This is achieved by utilizing robust lipid-based spheres (i.e., liposomes). These spheres hold surrounding water in a unique way, which in combination with their 3D morphology, offers a highly hydrated lipid-based interface during joint articulation that has been shown in laboratory tests to enable physical lubrication.
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E-Mail: contact@lipo-sphere.com