Who we are
Developing unique biolubricants for diverse
applications and markets

Liposphere Ltd. is an innovative female-led, biomedical Israeli start-up spun out from the Weizmann Institute of Science in early 2019. The company has developed CCoat® as a unique platform technology of unmatched, water-based biolubricants to deliver ultra-low friction and efficient lubrication for various medical and technological applications.

The remarkable discovery of the Hydration Lubrication Mechanism and its resulting technology, for which the company holds an exclusive IP license, has been established over the past two decades under the guidance of Prof. Jacob Klein at the Department of Materials & Interfaces, Weizmann Institute of Science. Built on this licensed IP, Liposphere has filed new patents paving the way for commercial manufacturing and production of various products.

Liposphere’s co-founders Dr. Ronit Goldberg (CEO) and Dr. Sabrina Jahn (CBO) have worked together under Prof. Klein’s academic setting for several years before spinning out Liposphere Ltd. The company is funded by the Israeli Innovation Authority as well as highly experienced investors.

The Spinoff Prize 2020, organized by Nature in partnership with Merck KGaA, has highlighted Liposphere as one of the 44 most exciting, science-based firms spun out from academic environments – A One to Watch.

In 2023, the Alliance for Advanced Therapies in Orthopaedics (ATiO), awarded Liposphere with the Best Early-Stage Company Award, judged by a high-profile orthopaedic audience, following competitive rounds of presentations.

 

Unique knowledge of hydration that has paved the way for developing unprecedented products

What we do

Liposphere’s Founders Team


Ronit Goldberg
Co-Founder, CEO

PhD in Chemistry, Weizmann Institute

// Innovative scientific leader and biotech entrepreneur with a PhD in chemistry and over 20 years’ experience in nanotechnology, drug delivery systems, and biomedical innovation. CEO of Liposphere Ltd., specializing in biocompatible biomaterials for ultra-low friction biomedical applications, and clinical trials. With a multidisciplinary approach from business to science via people. 


Sabrina Jahn
Co-Founder, CBO

PhD in Physics, University of Cambridge

//   Sabrina has profound experience in identifying new interdisciplinary research and product opportunities. She has a strong track record in successful governmental and private fundraising.

 

 

 

 

 

 

Supported by a highly experienced team of scientific, clinical and business advisors

Liposphere’s Management Team


Asaf Grupi
VP R&D

PhD in Physics, Bar-Ilan University

//   Asaf is a multidisciplinary researcher with over 20 years of experience in research design and implementation in various scientific fields, including lipid and protein biophysics. He has substantial expertise in the development of novel analytical methods, with 7 years of experience in managing R&D teams.

 

 

 


Natalie Harats
Head of Operations

MA in Logistics & Economics

//   Natalie is an operations manager with over 10 years of experience across various modalities of the field and a proven track record of streamlining processes and driving operational excellence. She holds an MA in Logistics, economics & interdisciplinary studies and has a strong background in ERP execution, procurement and overseeing IT management and office administration.

 


Margaux Zenou
Head of QA/RA

//   Margaux is an accomplished QA&RA professional with extensive experience in the medical device industry, leading regulatory strategy and quality management. With expertise in FDA, ISO13485, and EU MDR requirements, she has successfully guided teams through audits, regulatory submissions, and QMS implementations. Her leadership spans both startup and corporate environments, combining technical acumen with cross- functional collaboration. Margaux holds a BA in Educational Science, Hebrew University of Jerusalem, PRRC and experienced auditor.


Asi Harnoy
Head of Synthesis

Ph.D in Organic Chemistry from Tel-Aviv University

//   Asi holds a Ph.D in Organic Chemistry from Tel-Aviv University. He is passionate about organic synthesis and polymer chemistry, with a history of working in the pharmaceutical industry under GMP/GLP, and HPLC method development for more than 10 years. He is highly skilled in organic synthesis, molecular design, polymer chemistry, self-assembly processes, characterization of nano particles, and preparative chromatography.

 

 

 


Roman Sirota
Head of Analytics

PhD in Chemistry

// Roman holds a PhD in Chemistry. He is a professional with over seven years of experience leading analytical chemistry teams. He has a strong background in pharmaceutical chemistry and synthesis, with a focus on translating scientific knowledge into practical solutions. For the past three years, he has worked in the medical device industry, contributing to innovation at the intersection of chemistry, product development, and regulatory compliance.

 

 

 

Investor relations

Our mission and goals
Aiming for market leadership
with CCoat®

We aim to revolutionize the biolubricants market. Surfaces in motion are highly prevalent in nature and technology. In biological systems, concepts of friction, lubrication and wear are of utmost importance to maintain physiological function. In case of impairment to these elements, pathological conditions can arise. Clinically, high friction of sliding surfaces is often associated with pain.

Our vision includes innovative solutions for this problem in the orthopaedic and technological materials sectors, using Liposphere’s formulations to reduce wear and lower friction while improving lubrication and overall function.
Within technological and industrial fields, Liposphere’s water-based lubricants align with the global paradigm shift from oil-based lubricants towards more sustainable, green solutions, and can provide the market with revolutionary solutions.

 

Science & Technology
Experts in biolubrication

The scientific core behind Liposphere’s technology is the discovery of the groundbreaking Hydration Lubrication Mechanism, described in papers published in Science and Nature journals in recent years (1-3). This discovery has led to the development of Liposphere’s products.

Hydration lubrication allows for the understanding of friction and lubrication processes in aqueous media and biological systems. Sub-nanometer thick hydration layers able to resist high loads and pressures serve as the lubricating elements that form around zwitterionic groups, due to the large electric dipole of the water molecule. These hydration layers are the critical element behind the hydration lubrication mechanism. Hydrated elements situated between sliding, confined surfaces can bear a large load, while maintaining its strongly-attached hydration layer. Under shear these compressed hydration layers respond in a fluid manner if its relaxation rate exceeds the shear rate (4).

This combination of sustaining a large normal load, together with a fluid response to shear, results in striking lubrication properties. Applying this knowledge in our products allows Liposphere to manufacture highly hydrated, superlubricious biomaterials.

 

 

CCoat by Liposphere

Contact us

Would you like to contact us? Call us or send us a message using the contact form – looking forward to hear from you.

 

Liposphere Ltd.
Ha’arava 1
Giv’at Shmuel 5400804 
Israel

Office:  +972 (0) 732113227
E-Mail:  
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